# Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosis

> **NIH NIH U01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2022 · $446,507

## Abstract

PROJECT SUMMARY/ABSTRACT
While significant recent changes in the clinical care of people with HIV (PWH) (e.g., universal ART initiation,
greater use of statins as prophylaxis) have reduced cardiovascular disease (CVD) risk, concurrent
developments that may increase CVD risk (e.g., shift to integrase inhibitors as first-line HIV treatment,
continued aging of the HIV population) mean that the determinants of CVD in PWH are ever-changing. We
have the opportunity to extend our existing database of -omics measures in women in relation to HIV-
associated CVD in the MACS/WIHS Combined Cohort Study (MWCCS) to men, and expand the scope with
additional assessments of the microbiome, metabolome, and sex hormones. We propose to use archived
specimens to measure gut microbiota and selected microbiome-related metabolites and immune marker
panels, including markers of immune activation, gut barrier dysfunction and microbial translocation in relation
to carotid atherosclerosis in MWCCS men, and assess both the independent and mediating roles of sex
hormones in this relationship among both women and men with HIV. Our aims support HIV/AIDS research that
falls under the following NIH high priority AIDS-designated topics: 1) immune dysfunction, persistent
inflammation, and microbiome and genetic determinants that underpin the development of high priority HIV co-
morbidities, and 2) long-term treatment or prevention strategies for HIV-relevant comorbid conditions across
the lifespan.

## Key facts

- **NIH application ID:** 10661140
- **Project number:** 3U01HL146204-04S1
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Kathryn M. Anastos
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $446,507
- **Award type:** 3
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10661140

## Citation

> US National Institutes of Health, RePORTER application 10661140, Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosis (3U01HL146204-04S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10661140. Licensed CC0.

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