# Research and Methods Core

> **NIH NIH U54** · STANFORD UNIVERSITY · 2023 · $381,188

## Abstract

Research and Methods Core: Project Summary
The focus of our proposed UPSTREAM Research Center is examining the impacts of income intervention
programs for reducing the long-term burden of cancer in persistent poverty areas. Our proposal to achieve this
is through a scientific and collaborative process that prioritizes both the overlapping and also distinct needs of
the Latino and Vietnamese communities in the persistent poverty areas of Santa Clara County and Yolo
County, CA. The rationale for this approach is that there is robust evidence supporting a fundamental causes
approach to cancer prevention – that is, only through intervening on the “causes of the causes” will we make
substantial progress in reducing the cancer burden in persistent poverty areas. We cannot rely solely on
individual or group behavioral change interventions alone for population reductions in the cancer burden; we
must move ‘upstream’. The Research & Methods Core will support this mission through: Aim 1. Coordinating
data collection, measures and methods and ensuring the interoperability of both quantitative and qualitative
data within the Center and between Centers, Aim 2. Modeling the long-term effects of the project interventions
and other exposures on colorectal cancer incidence, Aim 3. Coordinating with the projects and Cores to create
data dashboards and insights with the persistent poverty communities in ways that will most benefit community
led actions in cancer prevention, Aim 4. Evaluating the Center’s research productivity and impact over the
funding period. The Research and Methods Core will address the needs of the Research projects by
coordinating the collection of similar measures across research projects to enable inference as to the relative
value of different income intervention programs, working with project investigators to coordinate
methodological approaches for inference, and coordinating with project investigators to use estimates from
their analytic data based models for inputs to a mathematical model that will predict population level changes
in colorectal cancer incidence in persistent poverty areas. Across all of the above processes, the Research &
Methods Core will evaluate the Center’s research productivity and impact over the funding period as part of the
leadership team aims outlined in the Administrative Core. The mission of the Research and Methods Core is
driven by two intertwining areas of intended impact – 1) robust and reproducible scientific discovery on the
impact of income interventions on preventing cancer in persistent poverty areas in combination with 2) building
capacity for cancer prevention research in those areas. Our team sees these as inseparable objectives.
Despite the compelling evidence for the impact of addressing social determinants of health as fundamental
causes of disease, less of this work has been based on actual interventions and actions, and even less of this
work in relation to cancer incidence. To build capaci...

## Key facts

- **NIH application ID:** 10661409
- **Project number:** 1U54CA280811-01
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** David H Rehkopf
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $381,188
- **Award type:** 1
- **Project period:** 2023-06-26 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10661409

## Citation

> US National Institutes of Health, RePORTER application 10661409, Research and Methods Core (1U54CA280811-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10661409. Licensed CC0.

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