# CORE B (Molecular Pathology Core)

> **NIH NIH P01** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2023 · $127,544

## Abstract

Abstract/Summary:
The Molecular Pathology Core will be located at the University of Miami under the direct supervision of Dr.
Oliver McDonald, MD, Ph.D., with collaborative support from Dr. Ladan Fazlollahi, MD, MPH at Columbia
University. This Core provides several essential services to P01 investigators. The Molecular Pathology Core
interfaces with existing infrastructure at the University of Miami to coordinate the collection of high quality
tissue specimens (human and animal) so that an experienced gastrointestinal pathologist can process them
into slide-based formats (H&E stains, TMAs, specialized chemical stains, immunohistochemical stains) that are
suitable for histopathologic microscopic evaluation. The Core also annotates, stores, and tracks tissue
biospecimens as they are collected and processed. Most importantly, the Core provides expert gastrointestinal
pathology consultation and diagnostic slide review, including H&E morphology, special stain interpretation, and
immunohistochemical (IHC) evaluation. These basic Core services are required for successful execution of
P01 projects, all of which require in-depth histopathologic characterization of Barrett’s Esophagus (BE) and
esophageal adenocarcinoma (EAC). The grading of BE-associated glandular dysplasia, grading and staging
esophageal adenocarcinoma, evaluating of in situ protein expression in these lesions, and implementating of
quantitative scoring systems are amenable to statistical tests of significance in collaboration with the
Biostatistics Core.

## Key facts

- **NIH application ID:** 10662327
- **Project number:** 5P01CA268991-02
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** Oliver Gene McDonald
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $127,544
- **Award type:** 5
- **Project period:** 2022-07-08 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10662327

## Citation

> US National Institutes of Health, RePORTER application 10662327, CORE B (Molecular Pathology Core) (5P01CA268991-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10662327. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*