ABSTRACT In its most recent research plan, the NHLBI’s National Center for Sleep Disorders Research identified the need to train investigators as its highest priority. The Harvard Medical School Division of Sleep Medicine Program for Training in Sleep, Circadian and Respiratory Neurobiology, based at the Brigham and Women’s Hospital, has been addressing this need since 1998 and has been modified to address the new challenges in our field. This program provides structured, comprehensive research training to prepare outstanding individuals for academic positions in the broad field of sleep science and sleep medicine. For each trainee, the training program consists of core required courses and activities, elective courses and activities, and an intensive research experience. Cross-disciplinary and translational research is a highlight of this program, and formal mentoring and tracking components are integral features. Intensive research training experiences are available across the breadth of sleep, circadian and respiratory neurobiology areas, including basic as well as clinical and translational research opportunities, with several program projects that span multiple laboratories and institutions. There are 15 Full Preceptors with extensive experience and demonstrated success at training predoctoral and post- doctoral fellows, well-funded research programs (training faculty have current research support totaling over $25 million of direct costs per year), and outstanding resources that trainees will utilize for research. In addition, we have 11 Associate Preceptors who also oversee our trainees, and are actively being trained to be our next generation of mentors. Our training record over the past decade reveals the success of our efforts to train leaders in academic sleep science. Of our pre- and post-doctoral trainees funded by this training grant over the last 10 years, >80% have remained in academic medicine (still in academic training or now in faculty positions). More than 40% of those still in academic medicine have already received external grant support as PI or Co- I with the remainder well on their way to independence. We propose to utilize this network upon networks to deliver an outstanding focused training program. Funds are requested for the implementation of an intensive training program on behavioral and social determinants of sleep and circadian health and their relationship to sleep health disparities, and to make this expanded curriculum widely available to all interested in the sleep, circadian, social science, and other research communities. This will be accomplished through the addition of biweekly lectures to our T32 curriculum as well an intensive 2-day in-person training program on our campus. Enduring training materials will be available in professional quality for widespread public access.