# Advanced Platform Technology Center

> **NIH VA I50** · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2022 · —

## Abstract

The Advanced Platform Technology (APT) Center addresses the pressing clinical needs of disabled
Veterans by harnessing the most recent developments in untapped engineering and basic science disciplines,
and applying them to design and disseminate new rehabilitation interventions. The Center facilitates the
creation and clinical translation of novel, cross cutting devices or methodologies within a framework that
promotes regulatory compliance, outsourcing by contract manufacturers, clinical testing, and dissemination
throughout the rehabilitation community. Its unique and supportive environment enables VA investigators to
develop advanced assistive or restorative technologies that serve Veterans with sensory, motor, or cognitive
deficits, as well as limb loss. The Center capitalizes on significant local expertise in pursuit of research and
development activities in three main clinical Application Areas: Prosthetics & Orthotics, Health Monitoring &
Maintenance, and Neural Interfacing. Innovative devices and foundational technical resources for the new
treatment paradigms to progress from proof-of-concept through first-in-man clinical feasibility testing in these
areas are developed by the Center’s Enabling Technology core. Center projects address new materials and
microsystems for communicating with the nervous system for novel neurotherapeutic or neuroprosthetic
interventions, mechanisms and optimal delivery of electrotherapy to accelerate wound healing or modulate
chronic pain, novel sensing systems for point-of-care blood analysis and personalized health, replacing or
restoring limb and pulmonary function, long-term monitoring of bladder status through wireless sensors, novel
active exoskeletons and articulated support structures that enable locomotion and stair climbing, and advanced
neurally-integrated prostheses to restore sensation to upper or lower limb amputees.
 The Center has established the internal engineering, quality control, and regulatory systems required for
successful translation of its discoveries to clinical implementation. Center programs facilitate generation and
protection of original intellectual properties, encourage interactions with the clinical services at the local
medical center, and identify, mentor, and retain talented clinician-scientists dedicated to improving Veterans
health. APT Investigators secure significant independent support from multiple local, national, governmental,
and private agencies, including major awards from NIH, DARPA, NSF, and DoD, in addition to Merit Review
and other VA funding, and disseminate their findings broadly in prestigious peer-reviewed journals, clinical and
scientific meetings, and the lay media. The Center also empanels Clinical and Industrial Advisory Boards, and
other mechanisms of governance and program evaluation that include representatives from Veterans Service
Organizations, to actively create productive collaborations with academic and commercial partners. The Center
estab...

## Key facts

- **NIH application ID:** 10663771
- **Project number:** 5I50RX001871-08
- **Recipient organization:** LOUIS STOKES CLEVELAND VA MEDICAL CENTER
- **Principal Investigator:** Gilles Pinault
- **Activity code:** I50 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2022
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2015-01-01 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10663771

## Citation

> US National Institutes of Health, RePORTER application 10663771, Advanced Platform Technology Center (5I50RX001871-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10663771. Licensed CC0.

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