# Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)-04 Supplement 5

> **NIH NIH U19** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $765,262

## Abstract

There are numerous barriers to research participation in Down syndrome (DS) that are also
complicated by ethnoracial health disparities. A disproportionately higher rate of African
American with DS die as young adults when compared to Whites with DS and little is known
related to differences in risk for a variety of age-related diseases in DS, including Alzheimer’s
disease. The overarching goal of the ADDORE Core is to generate culturally and linguistically
appropriate materials, in collaboration with community at large, for increasing awareness and
engagement of adults with DS from all communities into research aimed at understanding and
treating AD in this population. This core represents a near unique opportunity to engage
researchers and community stakeholders to inform best practices for increasing
diversity and engagement within the DS population. This INCLUDE administrative
supplement is in response to NOT-OD-20-024 and NOT-OD-21-076. This project represents a
unique opportunity to address the intersections between intellectual disabilities and race/
ethnicity. As most medical interventions and research studies have centered on white families
and those without intellectual disabilities, we recognize and have included community members
and those with actual family members with intellectual disabilities as subject matter experts.
Merging these community members with academic subject matter experts will only improve our
training, outreach and effectiveness. A community-led partnership that centers both families of
color and members of the intellectual disability community and their family members will provide
invaluable strategies to center those community members who have been typically excluded
from research.

## Key facts

- **NIH application ID:** 10665185
- **Project number:** 3U19AG068054-03S2
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Bradley T Christian
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $765,262
- **Award type:** 3
- **Project period:** 2020-09-30 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10665185

## Citation

> US National Institutes of Health, RePORTER application 10665185, Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)-04 Supplement 5 (3U19AG068054-03S2). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10665185. Licensed CC0.

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