ABSTRACT: CAREER ENHANCEMENT CORE The overall goal of the Career Enhancement Core at Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) is to train the next generation of multidisciplinary, independent scientists in Tobacco Regulatory Science. Under TCORS 3.0, the Core will continue to support the careers of post-doctoral associates and junior faculty motivated to become Tobacco Regulatory Science (TRS) investigators and support the career enhancement of established investigators who seek to pursue new areas of research. The Core will accomplish its goal by leveraging the successful training program developed in TCORS 1.0 and 2.0. Specifically, the Core will 1) select and appoint Scholars for a specialized career enhancement program in TRS; 2) provide didactic and experiential training on FDA regulation of tobacco products and TRS research, 3) invite speakers who are experts in TRS to enhance knowledge in timely and impactful TRS research and stimulate new interdisciplinary collaborations, 4) provide opportunities for scientific exchange through small travel grants to learn new methods, foster collaboration, and attend TRS and other scientific conferences, and 5) provide pilot research grants to stimulate novel research that addresses the FDA’s research priorities. The pilot grants will be available to Scholars, new researchers in TRS, or TRS researchers extending their research to novel areas, to stimulate research innovations. The Career Enhancement Core will provide a mechanism for review, funding, and ongoing oversight of pilot projects. All funded projects will receive assistance from the Laboratory Core, Administrative Core, and Measurement and Analytic Core to achieve their objectives. Through its services, the Career Enhancement Core will support the careers of new TRS researchers and stimulate TRS science to advance our scientific understanding of nicotine and flavors in tobacco products and support FDA’s regulatory authority.