# Vascular Training Grant

> **NIH NIH T32** · YALE UNIVERSITY · 2023 · $443,652

## Abstract

This is the fourth competing renewal application for Yale University’s Vascular Research Postdoctoral T32. Of
fellows who have completed training to date, 65% have obtained academic faculty positions and/or careers in
science, and many have received independent grant support, strong indicators of program success. The
continued goal is to provide laboratory and translational research training for highly qualified, diverse physician
(M.D. and M.D./Ph.D.) and Ph.D. postdoctoral fellows in vascular biology, in preparation for careers as
independent investigators in blood vessel biology- and medicine-related disciplines. Trainee selection will be
based on a commitment to vascular biology and strong prior research experience or potential of same.
Applications will be encouraged from clinical and basic science departments, with a nationwide competition for
7 yearly slots. Minority applicants will be specifically solicited through numerous avenues. 38% of the current
funding cycle fellows are underrepresented minorities. The training will be mentor-based, also including
advisory committees and didactic courses. The minimum duration of training will be 2 years. The
Cardiovascular Medicine Division and Yale’s Interdisciplinary Program in Vascular Biology and Therapeutics
will be the foundations for the program. A key asset is Yale’s interdisciplinary strength in vascular biology.
Departmental affiliations for participating faculty include Cardiovascular Medicine, Immunobiology,
Pharmacology, Pathology, Genetics, Bioengineering, Physiology, Cardiothoracic Surgery, and Computational
Science. Faculty were chosen based on impressive histories of mentorship, ongoing vascular research
productivity, strong extramural support and commitment to serve as mentors within the program. Examples of
research opportunities include: (1) molecular determinants and consequences of leukocyte-endothelial cell
interactions; (2) molecular imaging of angiogenesis and vascular remodeling utilizing nuclear and MR imaging
in animal models; (3) mapping and identification of genes that contribute to the development of vascular
disease (arterio-venous malformation, coronary artery disease) in humans; (4) engineering of vascular
biomaterials; (5) generation of angiogenic gene regulators for use in clinical trials and (6) novel single cell RNA
sequence analytic methods for determination of atherosclerosis-promoting cellular phenotypes. The last of
these represents a top tier computational science component newly added to our program. This is a wide
range of disease-related vascular research, with key translational components. Trainee progress will be
monitored by each mentor, the trainee’s advisory committee and the Program Co-Directors. It is the
expectation that we will train future national and international leaders in vascular research. Cardiovascular
disease is the leading cause of death in the U.S., and a major cause of mortality world-wide. This program will
provide important oppor...

## Key facts

- **NIH application ID:** 10666367
- **Project number:** 5T32HL007950-23
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** JEFFREY R. BENDER
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $443,652
- **Award type:** 5
- **Project period:** 2000-09-30 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10666367

## Citation

> US National Institutes of Health, RePORTER application 10666367, Vascular Training Grant (5T32HL007950-23). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10666367. Licensed CC0.

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