Project Summary: Clinical Research Resources Core The Clinical Research Resources (CRR) Core met its goals in the second funding cycle by developing and growing a multi-institutional research infrastructure and is now poised to grow further by deepening the partnership with clinical trial units at three more institutions and by supporting multi-institutional grants across the LA CaTS network. There are three Specific Aims for this next cycle defined as follows: Aim 1. Support clinical activity and ensure efficient and effective data collection in ongoing clinical trials including the All of Us study and the Long-COVID PASC/RECOVER trial. Aim 2. Expand support through development of infrastructure and human resources for clinical and translational research at LSU Health Shreveport and the VA and UMC hospitals in New Orleans. Aim 3. Enhance competitive clinical and translational research programs through training and professional development. Specifically, we will add a new marketing, recruitment and retention focus to our ongoing training activities. Aim 4. Extend the reach of CRR beyond the traditional clinical trial unit to engage underserved and underrepresented populations within the state. Specifically, we will collaborate with the Community Engagement and Outreach (CEO) Core to establish and maintain a network of disease-focused community members in New Orleans, Baton Rouge, and Shreveport. Network members will be recruited through CEO as well as Federally Qualified Health Centers and Agriculture Extension agents working with underserved and rural populations. Accomplishment of these aims will significantly enhance the infrastructure for clinical research in the State of Louisiana, leading to improved health outcomes and reduced health disparities for State residents with chronic diseases such as cancer, obesity, diabetes, and COVID-19.