# Collaborative Pediatric Critical Care Research Network - Clinical Site

> **NIH NIH RL1** · UNIVERSITY OF COLORADO DENVER · 2023 · $126,000

## Abstract

ABSTRACT – University of Colorado Denver 
With our participation in this iteration of the Collaborative Pediatric Critical Care Research Network (CPCCRN), 
we contributed to a series of discoveries that enhanced our understanding of disease processes and resulted in 
a multitude of potentially effective treatments for critically ill and injured children that require definitive evaluation 
in clinical trials. There continues to be tremendous need for a collaborative research network in pediatric critical 
care to facilitate the swift and effective translation of scientific and technologic discoveries into clinical advances. 
Access to appropriate patients and expertise in the execution of clinical trials must be linked to scientists and 
laboratories working within and across disciplines at the cutting edge of scientific advancement. At the University 
of Colorado Denver (UCD) and Children’s Hospital Colorado (CHCO), we have a long history of successful 
collaborative basic, translational, and clinical science programs focused on pediatric critical illness and injury. 
We will provide several unique areas of strength to the CPCCRN, including: 1) a distinctive multidisciplinary team 
of collaborative researchers with specific expertise in mechanistic investigations of cardiovascular and 
pulmonary diseases, 2) a proven and successful track record as a clinical site in CPCCRN, 3) expertise with 
pediatric clinical trials execution, including innovative programs to enhance positive research culture among 
clinical staff and participation among patients and families, 4) a 7-state catchment area with high volumes of 
critically ill and injured children, 5) an in-house rehabilitation program and extensive outpatient outreach program 
capable of providing follow-up care to nearly all our critically ill patients, and 6) a dynamic partnership with the 
Children’s Hospital Colorado Research Institute and Colorado Clinical Translational Science Institute to provide 
extensive research resources. Our ancillary site, Arkansas Children’s Hospital (ACH) provides 1) experience 
with pediatric clinical trials execution, including previous successful membership in CPCCRN 2) provision of care 
to nearly all of the critically ill children from the State of Arkansas and a 4-state catchment area, 3) representation 
of an Institutional Development Award (IDeA) state (historically received low levels of NIH support) and involving 
their unique populations (rural, Marshallese, and medically underserved communities) in the NIH mission, and 
4) a rich partnership with the ACH Research Institute and University of Arkansas Clinical Translational Science 
Award to provide comprehensive research resources. Utilizing these assets, we will augment the contributions 
of CPCCRN to the care of critically ill children through rigorous clinical trial execution, innovative translational 
and clinical trial proposals, participation in CPCCRN leadership committees, and training the next ...

## Key facts

- **NIH application ID:** 10667490
- **Project number:** 5RL1HD107775-03
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Eva S. Nozik
- **Activity code:** RL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $126,000
- **Award type:** 5
- **Project period:** 2021-08-18 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10667490

## Citation

> US National Institutes of Health, RePORTER application 10667490, Collaborative Pediatric Critical Care Research Network - Clinical Site (5RL1HD107775-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10667490. Licensed CC0.

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