C-DIAS RESEARCH CORE: PROJECT SUMMARY/ABSTRACT Improved access to evidence-based pharmacological and psychosocial treatments is urgently needed for persons with substance use disorders. Inequity in access to proven treatments is amplified in low-resourced communities and with organizations serving marginalized and underrepresented populations. The lack of rigor and consistency in methods, measures, design and approach undermines efforts to systematically learn how to implement evidence-based interventions across diverse settings. There is an enormous need for greater precision in how to implement and sustain proven interventions for addiction. Interventions and their delivery platforms are the “what” of an implementation endeavor, whereas implementation strategies are the “how” these interventions are installed and/or maintained. Only 2.4% of NIDA-funded research has examined the “how” of implementation strategies, and among these few, wide methodological variation exists. The Center for Dissemination & Implementation At Stanford (C-DIAS) Research Core integrates three teams of experts, led by top research scientists. The teams align with three domains necessary to advance implementation research in addiction: Methods & Measures, Design & Modeling, and Policy & Financing. Three complementary and innovative C-DIAS Research Projects will serve as open laboratories for Research Core activities. The Core will interact bi-directionally with the Research Projects, positioning each to accumulate and disseminate technical knowledge for the field. These synergistic efforts create an unprecedented opportunity for a deeper and accelerated examination of the mechanisms underlying how implementation strategies work, their contextual determinants, and how to select and deliver them to optimize implementation and clinical outcomes. The three Research Core teams, along with the Research Projects, will translate options about how to implement and at what cost for real-world decision-makers. The Research Core will: PREPARE the addiction research and practice communities with pragmatic and standardized methods and measures of implementation strategies for real-world implementation endeavors (Aim 1); IMPLEMENT rigorous examinations of the components and mechanisms of implementation strategies for effectiveness and cost, using innovative designs and modeling techniques, and creating decision-support tools for policymakers and systems leaders (Aim 2); and, SUSTAIN and scale-up evidence-based addiction treatments by identifying barriers, needed policy and financing strategies, and emerging solutions for ensuring their long-term, high quality and equitable delivery in community settings and health systems (Aim 3). Research Core activities directly address NIDA priorities to “better understand the barriers to successful and sustainable implementation of evidence-based practices and to develop implementation strategies that effectively overcome these barriers.” Not increm...