# Core D: Neuropathology Core

> **NIH NIH P30** · RUSH UNIVERSITY MEDICAL CENTER · 2023 · $384,650

## Abstract

ABSTRACT – NEUROPATHOLOGY CORE
The Neuropathology Core will play a pivotal role to help achieve the overall Rush ADRC goals by supporting,
promoting and facilitating innovative translational research. Specifically, the Neuropathology Core will promote
collaborative, transparent, and reproducible research by providing investigators with expertise, mentoring, and
a comprehensive and unique resource of biospecimens and data using contemporary laboratory methods,
state-of-the-art diagnostics, and sophisticated statistical support and data management. The Neuropathology
Core will do this in participation with the Administrative, Data Management and Statistical, Biomarker and
Neuroimaging, and Outreach, Recruitment and Engagement Cores, and the Research Education Component
working with ADRC core leaders and other colleagues and focusing on our well-characterized subjects in the
Clinical Core, Religious Orders Study (ROS) and Latino Cores. Specifically, the Neuropathology Core will (1)
Use rapid autopsy and optimal biospecimen collection procedures to obtain antemortem (blood, lymphocytes,
DNA) and postmortem (brain, cerebrospinal fluid) biospecimens (2) Preserve, process and store antemortem
(blood, lymphocytes, DNA) and postmortem (brain and CSF) biospecimens for clinical-pathologic and
innovative translational research by using uniform best practice procedures for research studies while
maintaining flexibility to accommodate special needs of specific researchers, studies, and collaborations. (3)
Perform state-of-the-art assessments on brain tissue using contemporary macroscopic and microscopic
procedures and collect state-of-the-art neuropathologic data and diagnoses, including data on AD, Lewy body,
TDP, and HS, and vascular (gross and microinfarcts, hemorrhages, atherosclerosis, arteriolosclerosis, and
cerebral amyloid angiopathy) pathologies to support a wide range of studies. (4) Distribute antemortem and
postmortem specimens and data, share expertise, and mentor junior researchers and faculty in
neuropathology by making biospecimens, data, and expertise assessable to junior and established
investigators within and across the ADRC community, and outside of the centers; also partaking in
collaborative studies with other centers and projects funded by the National Institution Aging (e.g., NACC,
ADGC) and other organizations seeking to advance research in AD/ADRD. (5) Catalogue all biospecimens,
photography, neuropathologic data and diagnoses, digital slide images and tissue distribution, using modern
and secure data management systems. These activities will support, promote and facilitate innovative
translational research that will lead to effective prevention, diagnosis, and interventions for Alzheimer’s disease
and Alzheimer’s Disease Related Disorders.

## Key facts

- **NIH application ID:** 10669643
- **Project number:** 5P30AG072975-03
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Julie A. Schneider
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $384,650
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10669643

## Citation

> US National Institutes of Health, RePORTER application 10669643, Core D: Neuropathology Core (5P30AG072975-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10669643. Licensed CC0.

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