NIH-DOD-VA Pain Management Collaboratory Coordinating Center Administrative Supplement Project Summary / Abstract Original The Pain Management Collaboratory Coordinating Center (PMC3) will (1) provide national leadership and technical expertise in all aspects of research supporting the design and execution of high impact Demonstration Projects that conduct cost-effective, large-scale, pragmatic clinical trials on nonpharmacological approaches for pain management and other comorbid conditions in veteran or military health care systems, and (2) make data, tools, best practices, and resources from these and other projects available to facilitate research partnerships in VA and DOD health systems. The PMC3 will leverage the expertise of the Pain Research, Informatics, Multimorbidities and Education (PRIME) Center of Innovation based at the VA Connecticut Healthcare System (VACHS) and its partners at VACHS and Yale, including the VA Cooperative Studies Program Coordinating Center/Clinical Epidemiology Research Center and the Yale Center for Analytical Sciences and Yale Center for Medical Informatics, enhanced by a strong partnership with colleagues at the Uniformed Services University for the Health Sciences Center for Rehabilitation Sciences Research and a novel Military Treatment Facility Engagement Committee comprised of collaborating DOD and university affiliated investigators, clinicians and educators devoted to facilitating successful pragmatic trials in DOD settings. We will use our expertise in pain management, electronic health records (EHR), data systems and the design and coordination of multi-site pragmatic trials to accomplish these objectives in collaboration with our VA, DOD and Yale partners. To achieve these objectives, three specific aims for this supplement will be addressed: Aim 1: To engage new projects in employing lessons learned and best practices; Aim 2: To support the design and execution of new demonstration projects; and Aim 3: To increase focus on refinement and enactment of Dissemination & Implementation plans. Achievement of these objectives and Specific Aims promise to significantly accelerate the integration of evidence-based nonpharmacological approaches for the management of pain and common co-occurring conditions into routine clinical care in military and veteran health care systems consistent with key recommendations from the National Pain Strategy.