# Adult Changes in Thought (ACT) Research Program Core F:  Data and Analysis Core

> **NIH NIH U19** · KAISER FOUNDATION RESEARCH INSTITUTE · 2023 · $1,622,000

## Abstract

CORE F. DATA AND ANALYSIS CORE ABSTRACT
The Adult Changes in Thought (ACT) U19 Research Program aims to better understand brain aging and
factors across the life course that influence cognitive outcomes and dementia. The ACT U19 Program will
achieve this aim by leveraging the study’s existing rich longitudinal data and by improving the study’s cohort
diversity, data sources, scientific and methodological scope, and capacity for data sharing. The ACT U19 will
answer new important scientific questions through its three research Projects that involve: understanding
relationships between 24-hour activity patterns and cognitive and functional aging (Project 1); assessment of
factors that differ across cognitively defined Alzheimer’s disease subgroups to better understand heterogeneity
in disease and its impacts (Project 2); and evaluation of the mechanisms by which common medication
classes may impact the brain and cognition (Project 3). To make this research endeavor possible, the ACT
U19 Program includes six resource Cores. Core F: Data and Analysis Core is one of these and plays a key
role by interfacing with all other Cores and Projects. The Data and Analysis Core’s primary functions in helping
the ACT U19 Program achieve its aims are three-fold: (1) manage a secure, multi-domain ACT Repository of
clinical, biological, and electronic health record data that are of the highest quality; (2) provide comprehensive
biostatistical and programmatic support to conduct analyses that answer the scientific questions of interest,
developing methods and innovating as necessary to address project complexities; and (3) facilitate efficient
data sharing with external researchers to promote broad use of ACT U19 data, thus upholding the promise that
this unique, publicly-funded resource holds for increasing understanding of dementia. The Data and Analysis
Core is organized around these three functions by structuring itself into an Informatics Unit, a Biostatistics Unit,
and a Data Sharing Unit. These Units are well positioned for serving these roles because the Core’s members
will be able to leverage their extensive biostatistical leadership experience, their scientific knowledge of
dementia and Alzheimer’s disease, their programmatic know-how and deep knowledge of data relevant for
ACT, and their demonstrated commitment to supporting public research through data sharing. The ambitious
research agenda of the ACT U19 Program requires a Data and Analysis Core team capable of facilitating high-
integrity data collection and sophisticated analytical frameworks that embrace complexity, and we are confident
that we have assembled a team that can meet these challenges and guide the ACT U19 Program to success.

## Key facts

- **NIH application ID:** 10672362
- **Project number:** 5U19AG066567-03
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Rod Walker
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,622,000
- **Award type:** 5
- **Project period:** 2021-05-15 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10672362

## Citation

> US National Institutes of Health, RePORTER application 10672362, Adult Changes in Thought (ACT) Research Program Core F:  Data and Analysis Core (5U19AG066567-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10672362. Licensed CC0.

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