# Physical activity, sedentary behavior, and sleep in the ACT cohort: The 24-hour activity cycle

> **NIH NIH U19** · KAISER FOUNDATION RESEARCH INSTITUTE · 2023 · $647,124

## Abstract

Physical activity (PA), sedentary behavior (SB), and sleep all impact cognitive and physical health in aging.
Most research to date has focused on how time spent in each of these behaviors individually impacts health
outcomes. However, interactions of PA, SB, and sleep likely account in part for the tremendous heterogeneity
in aging-related health outcomes, and their optimal balance across the 24-hour day in supporting healthy aging
is not known. This proposal capitalizes upon unique resources available through the Adult Changes in Thought
(ACT) U19 Program to explore the inter-relatedness of PA, SB, sleep, and longitudinal trajectories of cognitive
and physical health. The 24-hour activity cycle paradigm as a model for determining longitudinal inter-
relatedness of PA, SB, and sleep on health outcomes is innovative, as is our proposed collection of device-
based data to complement self-reported outcomes. This project proposes to use a number of innovative
statistical approaches to analyze the complex relationships between the 24-hour activity cycle and trajectories
of cognition and physical functioning. Scientific rigor is supported by objective monitoring of 24-hour behaviors
and builds upon more than two decades of ACT data in a well-characterized clinical population. Measures of
cognitive and physical function will include Cognitive Abilities Screening Instrument item response theory
scores, specialized tests of executive functioning and verbal fluency, self-reported activities of daily living, gait
speed, rising from a chair, and grip strength. For Aim 1, we will test bidirectional associations relating cognitive
and physical function to the 24-hour activity cycle using device-assessed measures of PA and SB, and self-
reported sleep. We hypothesize that (a) historically better cognitive and physical function will be independently
associated with higher levels of PA, lower SB, and better sleep in ACT participants, and (b) more PA, less SB,
and better sleep will be independently associated with better future maintenance of cognitive and physical
function. For Aim 2, we hypothesize that (a) historically better cognitive and physical function will be
independently associated with better device-assessed sleep quality and circadian rhythms in ACT participants,
and (b) better device-assessed sleep quality and circadian rhythms will be independently associated with
better future maintenance of cognitive and physical function. For both Aims, we will construct combined 24-
hour activity cycle profiles (based on different balances of PA, SB, and sleep) and explore how profiles are
associated with historical trajectories of and future changes in cognitive and physical function. Collaboration
with other Cores will provide new data about how Life Course and Clinical Core variables influence
associations, as well as new information about relationships between the 24-hour activity cycle and novel
neuroimaging data. Ultimately, our results will provide much ...

## Key facts

- **NIH application ID:** 10672368
- **Project number:** 5U19AG066567-03
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Dori E Rosenberg
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $647,124
- **Award type:** 5
- **Project period:** 2021-05-15 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10672368

## Citation

> US National Institutes of Health, RePORTER application 10672368, Physical activity, sedentary behavior, and sleep in the ACT cohort: The 24-hour activity cycle (5U19AG066567-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10672368. Licensed CC0.

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