# Bridging dataset generation to enable integrated data analysis and interpretation across HuBMAP tissues

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $150,000

## Abstract

PROJECT SUMMARY
The goal of this supplement is to generate bridging datasets across all HuBMAP tissues to allow the HuBMAP
Consortium to aggregate and integrate data and metadata from each tissue with respect to anatomical
references in a standardized manner to facilitate data integration, analysis and interpretation. We will perform
the 10x Genomics Chromium Single Cell Multiome ATAC + Gene Expression assay on snap- frozen tissue
samples for each organ across several Tissue Mapping Centers (TMC). This assay enables collection of RNAseq
and ATACseq data that are linked at the single-cell/single-nucleus level. We will link the individual tissue 10x
Multiome bridge datasets to each of the Anatomic, Structural, Cell Types and Biomarkers (ASCT+B) tables for
each organ to build a framework to input into the HuBMAP HIVE’s Registration User Interface. We will ensure
that these data (annotated with detailed biological and technical metadata) will be made available for broad use,
including not only the building of 3D multiscale maps that are the primary goal of this Consortium, but also
development of novel profiling technologies and computational approaches for analysis and integration of
multiple data types across multiple tissue types. We will rapidly release these bridge datasets to the TMCs to be
integrated with the organ-specific TMC spatial data to build spatially-resolved 3D tissue maps derived from this
common bridging dataset. As the Co-Chair of the HuBMAP Integrated Data Analysis & Interpretation Working
Group and through involvement with the Collaborative Projects and Publications Working Group planning the
cross-tissue integrative data analysis manuscript, we identified this important gap in the HuBMAP Consortium
datasets currently generated or planned to be generated at the HuBMAP 2022 Annual Meeting. Generating a
bridging dataset across all HuBMAP tissues will create an anchor for all individual organ atlases and enable
integrative analysis across consortium datasets to assess similarities and differences across tissues in cell count
composition, cell types and states, neighborhoods and functional units.

## Key facts

- **NIH application ID:** 10672692
- **Project number:** 3U54HD110347-01S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** LOUISE CHANG LAURENT
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $150,000
- **Award type:** 3
- **Project period:** 2022-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10672692

## Citation

> US National Institutes of Health, RePORTER application 10672692, Bridging dataset generation to enable integrated data analysis and interpretation across HuBMAP tissues (3U54HD110347-01S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10672692. Licensed CC0.

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