PROJECT SUMMARY – Clinical Science Core Progress towards meeting global public health tuberculosis (TB) targets for reductions in incidence, mortality and catastrophic costs have been slow, and appear to have stagnated due the recent COVID-19 pandemic. Without reinvigorating TB clinical research with an infusion of new investigators, novel perspectives, and cutting-edge innovation, we remain at risk of allowing the TB pandemic to continue unabated. The goal of the Clinical Science Core of the UCSF-UCB TRAC is to augment existing UCSF and UCB resources to accelerate clinical research by engaging New Investigators and established investigators new-to-TB, and by reducing the barrier to conducting high-quality, innovating clinical research. UCSF-UCB TRAC Clinical Science Core will support investigators by 1) providing consultation on key aspects of TB clinical research; 2) providing consultation about novel methodologic approaches in clinical research that may be applied to TB; 3) facilitating access to clinical cohorts, datasets, bio-specimens, and clinical research tools; 4) supporting meaningful community engagement via a TRAC TB Community Advisory Board; 5) supporting career development of new investigators with targeted mentorship. The Clinical Science Core will encourage an interdisciplinary approach to TB clinical research by making services and resources available for researchers from diverse fields including basic sciences, epidemiology, bioinformatics, public health, social sciences and clinical sciences. The Clinical Science Core hopes to attract and inspire a new generation of TB scientists to accelerate TB biomedical and clinical research with the support of UCSF-UCB TRAC faculty who are leaders in TB clinical sciences.