# The Influence of Vocal Loading Upon the Healing of Experimental Vocal Fold Injury

> **NIH NIH R21** · MIDWESTERN UNIVERSITY (GLENDALE AZ) · 2023 · $187,500

## Abstract

Project Summary
The development and maintenance of a speaking and singing fundamental frequency, while also achieving vocal clarity
throughout life, are important public health concerns. Symptoms of dysphonia are among the most common communication
disorders. Currently there is no treatment to restore a native vocal fold lamina propria composition or laryngeal movements
after injury. Research is limited because there is no in vivo model for larynx injuries that express a vocal behavior that can
serve as a reliable phenotypic marker. In general, an animal model can benefit research if its behavior can serve as marker
for the onset or the time-course of a pathology affecting a complex behavior. Specifically, the availability of an animal
model that combines experimental and genetic accessibility with important similarities to human voice production could
allow stronger inferences. Here we propose (1) to quantify key anatomical features of the vocal organ during postnatal
developmental in a new model, and (2) to describe the time-course of wound healing after experimental vocal fold injury in
a vocal dose- dependent fashion. Results will be integrated in a computational vocal fold model. Completion of this work
will provide the field with a new mouse model for the study of vocal disease mechanisms and therapeutic development. It
will also inform the role of vocal occupancy on the healing process of vocal folds.

## Key facts

- **NIH application ID:** 10674999
- **Project number:** 5R21DC019992-02
- **Recipient organization:** MIDWESTERN UNIVERSITY (GLENDALE AZ)
- **Principal Investigator:** TOBIAS RIEDE
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $187,500
- **Award type:** 5
- **Project period:** 2022-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10674999

## Citation

> US National Institutes of Health, RePORTER application 10674999, The Influence of Vocal Loading Upon the Healing of Experimental Vocal Fold Injury (5R21DC019992-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10674999. Licensed CC0.

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