# Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American women

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 2022 · $343,570

## Abstract

Project Summary/Abstract
African American women are 60% more likely to have postpartum hypertension and are nearly three times
more likely to die from preeclampsia than white women. Both during pregnancy and overall, hypertension in
African American women is more severe and presents earlier in life. In addition, compared to other ethnic-
racial groups, African American women have higher mortality rates from hypertension-related end-organ
damage like heart failure and stroke. Currently, however, no proven interventions exist to prevent or mitigate
the development of hypertensive heart disease during the postpartum period.
Using a randomized mechanistic clinical trial of guideline-directed medical therapy for postpartum African
American women with preeclampsia, we will advance knowledge of cardiac dysfunction in preeclampsia and its
possible treatments. We pursue a specific aim to answer these questions. AIM 1 is a randomized trial to test
whether guideline-directed medical therapy improves cardiac function and decreases blood pressure in
postpartum African American women with preeclampsia. This project innovates methodologically to
dramatically advance our understanding of a significant cause of morbidity and mortality in African American
women.

## Key facts

- **NIH application ID:** 10675331
- **Project number:** 3R01HL148191-02S1
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Sajid Shahul
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $343,570
- **Award type:** 3
- **Project period:** 2021-01-01 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10675331

## Citation

> US National Institutes of Health, RePORTER application 10675331, Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American women (3R01HL148191-02S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10675331. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*