ABSTRACT This application is being submitted to request the addition of an Affiliated Organization(s) to the Early Therapeutics Clinical Trial Network (ETCTN) UM1 Lead Academic Organization. The Chao Family Comprehensive Cancer Center (CFCCC) of the University of California, Irvine (UCI) has demonstrated to be a well performing site in the Create Access to Targeted Cancer Therapy for Underserved Populations (CATCH-UP) program, enrolling a total of 34 patients with nearly half (48%) coming from diverse patient populations (e.g. Latino, Asian and underserved areas). With the success of CFCCC’s participation in CATCH-UP, CFCCC will be integrated into the Pittsburgh Cancer Consortium (PCC), providing access for their patients to all ETCTN trials. The PCC will integrate CFCCC by providing regulatory support, data coordination and reporting of adverse events and outcomes on the studies led by UCI investigators. In addition, the PCC will support CFCCC through development of concepts and leadership in ETCTN trials. Conversely, CFCCC will use their experience and success in the CATCH-UP program to deploy best practices in underserved patient accrual in the PCC.