# Targeting lipid clearance pathways to promote repair after SCI

> **NIH NIH R01** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2023 · $454,078

## Abstract

PROJECT SUMMARY/ABSTRACT
After spinal cord injury (SCI), the injury site is filled with cellular debris, especially myelin debris that creates a
very unique lipid-dense environment. Macrophages are the predominant phagocyte that are responsible for
debris-clearance, but this process is not only inefficient, it is also maladaptive. The excessive amount of myelin
debris present at the injury site leads to formation lipid-laden macrophages (a.k.a. foamy macrophages) that
become pro-inflammatory and contribute to tissue regeneration failure. Therefore, understanding the
mechanisms of foamy macrophage formation after SCI may lead to novel therapeutic targets to promote repair
after SCI. In this application, we will investigate the molecular mechanisms of lipid accumulation in foamy
macrophages and how they contribute to fibrotic scar formation at the spinal cord injury site.

## Key facts

- **NIH application ID:** 10677106
- **Project number:** 2R01NS081040-10
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** Jae K Lee
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $454,078
- **Award type:** 2
- **Project period:** 2012-09-01 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10677106

## Citation

> US National Institutes of Health, RePORTER application 10677106, Targeting lipid clearance pathways to promote repair after SCI (2R01NS081040-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10677106. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*