# Transcriptional Regulation of Antibody Responses and Immunity

> **NIH NIH R01** · UNIVERSITY OF ARIZONA · 2023 · $531,017

## Abstract

ABSTRACT
The duration of antibody-mediated immunity varies widely with the specific immunization or infection for
reasons that remain difficult to understand or predict. The specific features of molecular circuitry in B cells and
plasma cells that are responsible for these differences have still not been defined. In this application, which
requests a second renewal of our R01 award, we seek to objectively define 1) molecular programs and cellular
trajectories that lead to long-lived plasma cells in primary responses; 2) transcriptional and epigenetic features
of memory B cells that precede durable recall responses. We will employ two BTB-POZ transcription factors
that functionally oppose each other to gain molecular footholds on programs that control plasma cell lifespan.
Modern single cell transcriptional and epigenetic programs will be employed alongside classic model antigens
and adjuvants and new genetic tools to manipulate genes in vivo. Though the experimental plan is
fundamental and basic in nature, the hope is that this work will lead to a set of rules that help predict and
optimize the duration of humoral immunity.

## Key facts

- **NIH application ID:** 10680051
- **Project number:** 2R01AI099108-11A1
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Deepta Bhattacharya
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $531,017
- **Award type:** 2
- **Project period:** 2012-09-24 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10680051

## Citation

> US National Institutes of Health, RePORTER application 10680051, Transcriptional Regulation of Antibody Responses and Immunity (2R01AI099108-11A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10680051. Licensed CC0.

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