# Investigating the Functions of RME8 in Parkinson's Disease

> **NIH NIH R21** · YALE UNIVERSITY · 2023 · $251,250

## Abstract

SUMMARY
The DNAJC protein family (DNAJC5-26) is a subclass of co-chaperones that has attracted recent attention due
to the identification of mutations that are linked with parkinsonism. Here, we focus on DNAJC13, which encodes
Receptor-Mediated Endocytosis 8 (RME8), a co-chaperone that facilitates membrane recycling and cargo sorting
of endocytosed proteins. RME8 is primarily localized at the early endosome membrane which serves as a
switchboard for protein and membrane traffic. In Parkinson’s disease (PD) patients, different mutations of RME8
have been identified, however, more evidence are needed to understand the roles of RME8 in Parkinsonism in
vivo. Our proposal will systematically evaluate the 1) behavioral, 2) pathological and 3) cellular changes in novel
RME8 mouse models, as a function of age, and determine if they replicate PD features. Our objective is to define
the functions of RME8 in Parkinsonism and identify points of therapeutic intervention for PD.

## Key facts

- **NIH application ID:** 10681663
- **Project number:** 1R21NS132546-01
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Sreeganga S Chandra
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $251,250
- **Award type:** 1
- **Project period:** 2023-03-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10681663

## Citation

> US National Institutes of Health, RePORTER application 10681663, Investigating the Functions of RME8 in Parkinson's Disease (1R21NS132546-01). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10681663. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*