Abstract – Research and Methods Core The Research and Methods Core (RMC) will provide scientific, technical, and regulatory expertise and support to the STELLAR Center and specifically the Rapid Cycle Pilot studies, Field Trial, and Pragmatic Trial. The RMC, through working groups lead by expert investigators, will provide critical guidance on all Center research activities. It will oversee development, implementation, and evaluation of Center research, promote common data elements, and work with the Administrative Core to facilitate dissemination of research findings. In conjunction with the Clinical Practice Network, the RMC will develop and test the pipeline of patient entry into telehealth promotion services such that patients and providers alike are aware and desire program entry, that it is accessible to all, and that it garners enrollment of a diverse representation of cancer patients. Specifically, the RMC will provide the expertise necessary to develop, integrate, and implement common and customized digital tools to support telehealth intervention and assessment. The RMC will use mixed (qualitative and quantitative), effectiveness, and implementation research methods and provide biostatistics and informatics support for all research goals. It will additionally support development of grant proposals for novel projects; improve quality, rigor, innovation, and cost-effectiveness of the proposed studies, and disseminate research findings and evidence-based telehealth interventions, care delivery models, and/or implementation strategies to multiple stakeholders. The STELLAR RMC will be comprised of 4 key working groups. The Telehealth Behavioral Interventions Working Group will support the development and harmonization of intervention materials and tools. The Measures and Methods Working Group will provide research management and oversight as it pertains to measures, assessments, outcomes, and research methodology. The Informatics Integrations Working Group will facilitate the design, development, and integration of electronic data capture, common data elements development, and key technology tool integrations to optimize the telehealth workflow. Finally, the Data Analytics and Biostatistics Working Group will provide data management, statistical support, analytics, and economic evaluation for the Center’s projects, including novel method development and evaluation. In sum, the STELLAR RMC will enhance productivity by enabling investigators to conduct their funded projects more efficiently and effectively and support cutting edge research by supporting and facilitating innovative tool, method, and measures development and dissemination.