The Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) will develop a robust clinical and translational research (CTR) infrastructure for Hawaii to reduce health disparities among indigenous Pacific People (IPP; i.e., Native Hawaiians, Other Pacific Islanders, and Filipinos) and other underserved populations in Hawaii. PIKO is a partnership between the University of Hawaii (UH), Hawaii Pacific University (HPU), and Chaminade University of Honolulu (CUH), and stakeholders serving IPP communities. PIKO takes a team- science approach to transform current health promotion paradigms and to accelerate the pace of CTR advances to improve IPP health and wellbeing. The PIKO Administrative (ADMIN) Core will function as a central coordination and communication hub to maximize scientific innovations, facilitate interactions among partners, foster idea-exchange, promote team science, enhance career development, and champion community engagement; to coordinate the sharing of resources across existing NIH and NIGMS program grants at UH and partnering institutions; to develop operational efficiencies to decrease administrative burdens on Core Directors and pilot-funded investigators. The Specific Aims of the ADMIN Core are as follow: Specific Aim 1: Oversee coordination of CTR activities and resource allocation by managing and supervising all research, mentoring, and career development activities; by providing scientific and regulatory oversight to be responsive to institutional and programmatic changes; by engaging the expertise of the advisory committees and integrating their recommendations; by developing and managing operating policies and procedures; and by ensuring scientific and fiscal flexibility by prioritizing and managing the allocation of fiscal and other resources. Specific Aim 2: Oversee strategic planning, inter-institutional coordination, and communication by organizing and facilitating an annual strategic planning process to monitor progress and ensure milestones are met within the proposed timelines; by fostering collaboration and interaction among participating institutions, Cores, investigators, and other stakeholders; by coordinating sharing of resources between NIH-funded programs and institutional infrastructure Cores; by managing conflict adjudication and dispute resolution processes and procedures; and by managing all internal and external communication and dissemination strategies to ensure effective and timely information exchange between PIKO’s partners, Core directors, investigators, and staff. At the end of the 5-year project period, PIKO will have expanded and diversified the CTR portfolio at UH and partner institutions, increased efficiency and access to CTR Core operations, enhanced CTR productivity and collaboration, heightened CTR competitiveness and grant award success, and accelerated the career development of junior investigators and other CTR investigators, especially IPP investigators.