# Integrative Bioinformatics Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $175,184

## Abstract

ABSTRACT
Precision medicine is an emerging integrative approach for disease prevention, early detection and treatment
that takes into account individual variability in genetics, medical history, environmental exposures, and lifestyle.
The development and availability of genomic and other molecular profiling technologies, particularly with recent
advances in single-cell profiling, in combination with the deployment of electronic health records (EHR) provide
an unprecedented opportunity to apply precision medicine strategies in rheumatic disease research. The goal
of the Integrative Bioinformatics (IB) Core is to provide researchers with state-of-the-art computational
approaches for the study of rheumatic disorders. Directed by leading experts in computational biology and
bioinformatics, the IB Core will provide investigators with assistance in study design; bioinformatics analysis of
clinical and bulk- and single-cell omics data; data integration; and data dissemination. To advance rheumatic
disease research in the context of precision medicine, the IB Core will work in collaboration with the Genomic
Technology (GT) and Clinical Data Informatics (CDI) Cores to provide tools and workflows for the analysis and
integration of high quality genomic, molecular and clinical data. With those goals in mind we propose the following
aims. In Aim 1, we will provide analytical consulting services in study design, data analysis and data integration
with public datasets in order to advance precision medicine in rheumatic disease research. In Aim 2, the IB Core
will develop novel tools, software and analytical pipelines for the integration, annotation, analysis, retrieval, and
presentation of data from clinical and molecular studies of rheumatic diseases including single-cell sequencing
and CyTOF data. As a result of this Aim, we will furthermore establish and maintain a technologically up-to-date
toolset that can be readily used for systems-level analyses of the data. Aim 3 is to integrate molecular and
clinical data and leverage collaborations between the GT and CDI Cores to facilitate integrative computational
analysis for a wide range of clinical, translational and basic research studies to enable precision medicine in
rheumatology. Finally, in Aim 4, we will provide centralized internal and external data management and storage
including assistance in real-time project development using the UCSF Data Library and in dissemination of data
for P30 associated projects using the Immunology Database and Analysis Portal (ImmPort). The IB Core will
bring together researchers from different backgrounds and enable investigators whose work can benefit from
access to state-of-the-art computational technologies and approaches, with an overall goal of advancing
precision medicine in rheumatology.

## Key facts

- **NIH application ID:** 10685567
- **Project number:** 5P30AR070155-08
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** MARINA SIROTA
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $175,184
- **Award type:** 5
- **Project period:** 2016-09-21 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10685567

## Citation

> US National Institutes of Health, RePORTER application 10685567, Integrative Bioinformatics Core (5P30AR070155-08). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10685567. Licensed CC0.

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