# UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource

> **NIH NIH U54** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2023 · $154,733

## Abstract

ABSTRACT
It is the goal of the UAB-Childhood Cystic Kidney Disease Core Center (CCKDCC) to work with the other U54
PKD Centers, under the direction of the U24 Coordinating Center Site (U24-CCS) to reduce obstacles in cystic
kidney disease research leading to more rapid translational studies by PKD Consortium Members and
development of novel therapeutics. The UAB-CCKDCC will help address the limitations associated with the small
CCKD patient population available at individual intuitions by providing access to clinical data and biomaterial
from human CCKD patients from across the Americas. The Center will focus on the development of resources
to analyze cilio-cystic disease protein function, localization, and interactions. The UAB-CCKDCC has assembled
a multidisciplinary team of researchers to carry out these goals and actively recruit new and established
investigators to the field. The Center will generate and provide researchers with patient relevant models of CCKD
and establish methodology to utilize these models to ascertain the efficacy of candidate therapies to slow disease
progression using a standardized, cost-effective, and longitudinal imaging strategy. The resources provided by
the CCKDCC will help address several of the most significant hurdles slowing the development of therapeutic
approaches and strategically recruit new scientists into the field.
The Clinical, Translational, and Biorepository Resource (Core A) will compile clinical data, genetic information,
and biological specimens from patients with recessive HRFD, as well as launch the US node of ADPedKD, an
international, multicenter observational study of childhood ADPKD. This centralized resource is designed to
accelerate discovery research in childhood cystic kidney diseases (partnership with Cores B and C). Integration
of these resources under a unique identifier, combined with rigorous, detailed interviews of patient/caregiver
health research experiences will inform the development of new, targeted interventional strategies (partnership
with Core D). The Core will coordinate efforts with other U54-RTCCs, under direction of the U24-CCS and
NIDDK, to develop and make the resources available to the PKD Research Consortium.

## Key facts

- **NIH application ID:** 10685977
- **Project number:** 5U54DK126087-04
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** LISA MARIE GUAY-WOODFORD
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $154,733
- **Award type:** 5
- **Project period:** 2020-07-20 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10685977

## Citation

> US National Institutes of Health, RePORTER application 10685977, UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource (5U54DK126087-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10685977. Licensed CC0.

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