# Animal Resources

> **NIH NIH P30** · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2023 · $184,991

## Abstract

ABSTRACT – ANIMAL RESOURCES SHARED RESOURCE
The Animal Resources Shared Resource is a Cancer Center-managed Shared Resource that provides a
comprehensive animal care and use program for Center investigators. The facility has been AAALAC-accredited
since 1988. The Core provides five basic types of services: (1) husbandry and equipment sanitation/sterilization,
(2) mouse breeding procedures and maintenance; (3) procedural techniques training and support; (4) in vivo
imaging, blood analysis, and irradiation; and (5) veterinary services and administrative/IACUC support. The
animal facility currently occupies 25,602 sq. ft of space in four buildings. Mice are the primary species used, with
occasional housing of rats. Over the last 5-year grant period, AR averaged 8,389 occupied mouse cages per
month, with growth in the last 2 years to more than 9,000 cages/month. The mice are housed in individually
ventilated caging systems. There is sufficient capacity for growth, as the facility is capable of maintaining up to
13,000 cages but generally operates at ~70% capacity, which facilitates breeding colony maintenance and
protocol housing requirements. AR provides full-service animal care that includes all husbandry as well as setting
up breedings, weaning litters, obtaining tail samples, maintaining animal pedigrees, census and IDs. This
comprehensive service is also cost-effective, with the per diem including those services at $0.72/cage for
standard mice. The AR staff perform an additional range of services for Center investigators, including
intravenous (tail and retro-orbital veins), subcutaneous, intradermal, intramuscular, intraperitoneal, and
mammary fat pad injections, oral gavage, tumor measurements, blood and tissue collection, body weights,
perfusions, and pre- and post-operative surgical care. The Core provides essential scientific support to Center
members by supplying animal models and expert technical assistance for investigation of tumor development
and growth in vivo. The Tumor Analysis facility is a key resource in this respect, providing access to a variety of
xenograft models, including patient-derived xenografts, and further assisting with the experimental design and
carrying out studies of genetic factors or experimental compounds that influence tumor growth and metastasis.
This service is supported by an array of sophisticated imaging modalities for evaluating tumor progression,
including luminescence, fluorescence, and ultrasound. Additional Animal Analysis services include blood cell,
serum, behavioral, and metabolic analysis. In the past five years, 44 Investigators from all three Cancer Center
programs have made extensive use of the Animal Resources, and the Core has provided support for the
publication of 116 cancer-relevant papers by Cancer Center investigators.

## Key facts

- **NIH application ID:** 10686124
- **Project number:** 5P30CA030199-42
- **Recipient organization:** SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- **Principal Investigator:** Alessandra Sacco
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $184,991
- **Award type:** 5
- **Project period:** 1997-05-01 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10686124

## Citation

> US National Institutes of Health, RePORTER application 10686124, Animal Resources (5P30CA030199-42). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10686124. Licensed CC0.

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