# Biomarkers for Peripheral Circadian Clocks in Humans

> **NIH NIH R56** · UNIVERSITY OF COLORADO · 2022 · $779,461

## Abstract

PROJECT SUMMARY/ABSTRACT
Circadian clocks are present in most tissues of the body with importance for optimal physiological function and
behavior. Misalignment or disruption of peripheral circadian clocks contribute to disease and thus represent
promising novel treatment targets to improve health. The overall goal of this proposal is to improve our
understanding of peripheral circadian clocks in humans. We will conduct a seven-weeklong randomized,
crossover, mechanistic clinical trial to 1) test zeitgebers (time cues) for already identified markers of peripheral
clocks, and 2) identify novel biomarkers for peripheral clocks and explore zeitgebers for those clocks in humans.
Preliminary data from our human circadian basic and clinical trial research set the stage for this proposal. This
mechanistic clinical trial effort is a first step to inform future development of novel circadian based treatments for
aligning peripheral clocks and for developing novel circadian biomarkers that will advance our scientific
understanding of circadian rhythms. Our overall goal and aims support the NIH Precision Medicine Initiative and
the NIH Sleep Disorders Research Strategic Plan.

## Key facts

- **NIH application ID:** 10687428
- **Project number:** 1R56HL165343-01
- **Recipient organization:** UNIVERSITY OF COLORADO
- **Principal Investigator:** Kenneth P Wright
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $779,461
- **Award type:** 1
- **Project period:** 2022-09-20 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10687428

## Citation

> US National Institutes of Health, RePORTER application 10687428, Biomarkers for Peripheral Circadian Clocks in Humans (1R56HL165343-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10687428. Licensed CC0.

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