PROJECT SUMMARY – Core A (Administrative Core) Yale TMC aims to map cellular senescence in primary (bone marrow and thymus) and secondary (tonsil and lymph node) lymphoid organs, which requires assembling a highly multidisciplinary team with diverse expertise to characterize and understand cellular senescence and associated environments in human tissues. The Administrative Core is led by Drs. Fan and Halene, whose have a long-standing record of active collaboration, extensive experience in NIH consortium activities, and the management of large team projects. A program manager will coordinate all administrative activities within Yale TMC and the communications with NIH SenNet program staff. Specifically, the Administrative Core will fulfill the following key functions: (1) establish a leadership plan and the operation structure to supervise and manage all research activities, set up a decision- making procedure for the TMC’s governance, establish supervisory mechanisms to ensure effective internal management of ongoing research and participation in SenNet activities; (2) establish the TMC coordination plan including communications and collaborations between the Cores within Yale TMC, define and monitor specific responsibilities of each Core, manage the pilot grant projects, evaluate progress and milestones, and develop strategies to minimize confounding factors in data generation and sharing; (3) develop a SenNet consortium coordination plan including participation in the steering committee to improve and implement operation protocols, joining or creating new interest groups such as “spatial omics” and “immune cell senescence”, make commitment to work with CODCC and other TMCs for protocol and data integration and sharing, and mange trans-network collaborations. We will adhere to Network-wide policies and procedures established by the NIH and the SenNet Steering Committee, including data access, publication, and intellectual property policies. We will also abide by, Memoranda of Understanding and other sharing agreements potentially needed for data and biospecimen sharing within the Network and other related programs. The Administrative Core will develop outreach activities to enhance data dissemination and utilization by the large research community to improve our understanding of cellular senescence, heterogeneity and associated environments in development, aging, and disease.