# Clinical Coordinating Center for the Acute to Chronic Pain Signatures Program

> **NIH NIH U24** · UNIVERSITY OF IOWA · 2022 · $376,914

## Abstract

PROJECT SUMMARY/ABSTRACT
The transition from acute to chronic pain has eluded researchers for years, likely due to its complex nature and
the inherent individual variability. The ability to identify individuals at risk, and those with reduced risk, for the
transition to chronic pain using biomarkers will advance personalized acute pain treatment strategies, reduce
reliance on opioid pharmacotherapy, and help identify novel therapeutic targets, thereby transforming the
management of acute pain events. The Acute to Chronic Pain Signatures (A2CPS) Program aims to identify
biomarkers and their collective biosignatures (a combination of several individual biomarkers) that predict
susceptibility or resilience to the development of chronic pain after an acute pain event through the
development of a large consortium. The advantage of multisite observational studies is their ability to
comprehensively phenotype large population cohorts across multiple biopsychosocial domains in a relatively
short time. This application describes a partnership between a strong group of pain scientists (Sluka, Frey
Law) and the Clinical Trials Statistical and Data Management Center (Coffey, Ecklund) at the University of
Iowa. The proposed CCC applies thorough and well-organized principles to facilitate, support and enhance the
scientific rigor and effectiveness of key stakeholders for the identification of critical biomarkers for the acute to
chronic pain transition, using the following task-based specific aims: 1) Lead the development and
implementation of clinical protocols. 2) Provide oversight and management of collaborative activities across the
consortium to support the overall goals of A2CPS. And 3) Facilitate transparent and effective communication
between consortium members. The CCC will support study design, bringing expertise in pain and adaptive
designs to help identify biomarkers for study inclusion; promote efficiency and quality through development of
milestones, Standard Operating Procedures (SOPs), individualized recruitment plans, and staff training
protocols. The CCC will be responsible for regulatory procedures including: standardizing the electronic health
record; coordinating a central Institutional Review Board (cIRB); and convening a Data Safety and Monitoring
Board (DSMB). The CCC will track protocol quality control procedures and safety monitoring; perform central
monitoring and on-site monitoring visits; and monitor progress towards A2CPS milestones, particularly site-
specific enrollment and retention targets, a critical component in the success of the A2CPS initiative. The
success of the A2CPS Program is dependent on effective management and coordination of activities across
the Consortium. We have assembled a team with expertise spanning pain science, clinical trials in patients
with pain and other conditions, and successful large multi-site trial coordination. The University of Iowa has a
highly collaborative environment with strong pain scien...

## Key facts

- **NIH application ID:** 10690109
- **Project number:** 3U24NS112873-04S3
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** CHRISTOPHER S. COFFEY
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $376,914
- **Award type:** 3
- **Project period:** 2019-08-15 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10690109

## Citation

> US National Institutes of Health, RePORTER application 10690109, Clinical Coordinating Center for the Acute to Chronic Pain Signatures Program (3U24NS112873-04S3). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10690109. Licensed CC0.

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