# Biospecimen/Bioimaging Core

> **NIH NIH U54** · STANFORD UNIVERSITY · 2023 · $317,902

## Abstract

ABSTRACT – BIOSPECIMEN / BIOIMAGING CORE
The Biospecimen/Bioimaging Core leverages infrastructure of the Stanford Urology and Pathology
departments, but augments services to benefit O’Brien Center investigators. Led by a qualified team, the
centralized resource provides qualitative advantages and efficiencies of scale. The Core procures and provides
Center investigators with needed biospecimens, including fresh, freshly-frozen, and formalin-fixed paraffin-
embedded (FFPE) prostate issues. The Core also performs less visible but equally important activities,
including patient consent, quality control/assurance, database management, clinicopathologic annotation, and
regulatory compliance. In addition, the Core provides tissue characterization services, including histology,
tissue microarrays, laser microdissection, and multiplex immunohistochemistry (IHC) using MIBI-TOF
(Multiplexed Ion Beam Imaging by Time of Flight). MIBI-TOF is a powerful and robust technology that
harnesses metal-tagged antibodies for the simultaneous quantification of 40 or more antibody targets, with
superior spatial resolution and dynamic range. The Core also stores and provides portal access to images
including prostate MRIs, whole-mount histology and IHC, and MIBI-TOF data, as well as an integrated multi-
scale prostate Atlas spanning MRI to histology, cells and molecules. The Biospecimen/Bioimaging Core
provides essential tissue procurement, characterization and imaging services to support the three Center
Projects, the Education Enrichment and Opportunity Pool programs, as well as outside O’Brien Centers, P20
grant programs, and the broader benign urology community, .

## Key facts

- **NIH application ID:** 10690583
- **Project number:** 5U54DK130065-03
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Robert B West
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $317,902
- **Award type:** 5
- **Project period:** 2021-09-15 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10690583

## Citation

> US National Institutes of Health, RePORTER application 10690583, Biospecimen/Bioimaging Core (5U54DK130065-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10690583. Licensed CC0.

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