# UAB Pilot Center for Precision Animal Modeling (C-PAM) - Disease Modeling Unit

> **NIH NIH U54** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2023 · $900,399

## Abstract

ABSTRACT (DISEASE MODELING UNIT)
The C-PAM Disease Modeling Unit (DMU) supports the UAB Center for Precision Animal Modeling (C-PAM) by
creating and validating innovative animal models that recapitulate patient disease at both molecular and
phenotypic levels so that we can better understand disease pathogenesis and make highly relevant models
ready for preclinical testing. Based on input from Preclinical, Bioinformatics, and Coordinating Sections, the DMU
creates patient driven variant alleles in model organisms including C. elegans, zebrafish, mice, and rats to
functionally analyze nominated human variants suspected of causing disease. The resulting innovative models
are subject to rigorous and standardized phenotypical characterization prior to distribution by the Resource and
Services Section. The DMU focuses initially on demonstration projects related to disease models and pathways
associated with several areas of strength at UAB including ciliopathies, cohesionopathies, and rasopathies,
neurological/ neurodevelopmental, musculoskeletal, cardiovascular, and immunological disorders. Community
nominated projects selected for genetic model development begin in year 2 with generated models thoroughly
characterized by the team of investigators associated with C-PAM and the nominating clinician or researcher.

## Key facts

- **NIH application ID:** 10690594
- **Project number:** 5U54OD030167-04
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** ROBERT A KESTERSON
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $900,399
- **Award type:** 5
- **Project period:** 2020-09-10 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10690594

## Citation

> US National Institutes of Health, RePORTER application 10690594, UAB Pilot Center for Precision Animal Modeling (C-PAM) - Disease Modeling Unit (5U54OD030167-04). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10690594. Licensed CC0.

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