Project Summary/Abstract: National Diabetes Policy Research (DPR) Resource Core To promote health equity across the diabetes continuum, a new generation of translational research must address the larger systems that generate or undermine health – from clinical healthcare systems to public health systems to social systems. Diabetes policy research increasingly relies on methodological expertise in five key areas: (1) natural experiments research; (2) health economics including comparative effectiveness and cost-effectiveness analysis; (3) simulation modeling; (4) machine learning; and (5) communicating science to policy-making institutions, community partners, health departments, and human service organizations. As National Resource Core within the Diabetes Research for Equity through Advanced Multilevel Science Center for Diabetes Translational Research (DREAMS-CDTR), the National Diabetes Policy Research Resource Core (National DPR Core) will extend the reach of the CDTR expertise and resources beyond the primary institutions by leveraging cutting-edge and robust methodologies; improving the uptake of research across diverse focused on high-risk populations; and enhancing the efficiency, productivity, effectiveness, and multidisciplinary nature of diabetes translation research through allocation of on-demand availability of experts across the five key areas listed above. The National DPR Core will draw upon the research expertise in diabetes at UCSF, UC Davis, UC Merced and Kaiser Permanente Northern California, which together have a focus on promoting health equity among vulnerable populations and a specific portfolio of research and translation of interventions to reduce socioeconomic and race/ethnic disparities in diabetes prevention and treatment outcomes. These include policies related to social and structural determinants of health such as health literacy, food insecurity, healthy food access and sugary beverage consumption, health insurance design, access to health information technology, and barriers to safety net clinic programs. The National DPR Core will be dedicated solely to expanding core services to investigators and others outside of the DREAMS-CDTR, offering collaborations between epidemiologists, economists, and health service researchers; and facilitating linkages to community health plans, public health departments and social service agencies for diabetes researchers.