# COBRE Center on Opioids and Overdose

> **NIH NIH P20** · RHODE ISLAND HOSPITAL · 2022 · $134,624

## Abstract

PROJECT SUMMARY
We propose to build and sustain the Center of Biomedical Research Excellence (COBRE) on Opioids and
Overdose at Rhode Island Hospital and affiliated research institutions. The motivation for this effort lies in the
tremendous need for greater scientific understanding of the mechanisms underpinning vulnerability to opioid
use disorder and a need for more effective interventions to treat and prevent opioid misuse and overdose. We
will approach these challenges through ongoing, cooperative partnership among senior scientists and early
career investigators across several complementary disciplines. We propose a unique and innovative mentoring
strategy that, in addition to primary project advising, will provide junior faculty members with specialized
mentorship and services that empowers investigators to influence policy and practice through their research.
Moreover, we will build four interdisciplinary cores that will provide infrastructure, consultation, and additional
support services to ensure the successful career development of our Project Leaders. The long-term goal of
the Center is to develop and sustain a critical mass of investigators specializing in opioids and overdose that
benefits affected populations and enhances the competitiveness of affiliated investigators. The objective of this
proposal is to establish and build the COBRE Center and to support the research activities of junior Project
Leaders to ensure their transition to R01-funded scientists. There are two Specific Aims—one related to the
establishment of a new disease-specific research center, and one encompassing four Research Projects that
are linked by the themes of opioids and overdose. Aim 1: Establish the cores needed to develop and sustain a
thematic multidisciplinary center of research excellence on opioids and overdose. Four cores will be created to
achieve this aim: an Administrative Core, a Data and Research Methods (DRM) Core, a Translational and
Transformative (T2) Core, and a Special Populations (SP) Core. Aim 2: Support the selection, mentorship, and
career development of early career faculty Project Leaders. The four initial research projects are: Project 1:
(Beaudoin) “Informed opioid prescribing for acute musculoskeletal pain after motor vehicle collision: A support
tool for assessing risks and benefits of analgesic medications before prescribing (STAAMP),” Project 2:
(Claborn) “Prevention of Opioid Overdose following Incarceration: Leveraging Mobile Health Technology,”
Project 3: (Becker) “Contingency Management in Combination with MAT for Opioid Use Disorders,” and
Project 4: (Czynski) “Neonatal Abstinence Syndrome (NAS): Fetus to First Years.” The proposed center will
bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and
distinguished advisors and collaborators to work closely together to establish a center of excellence in an area
of clinical research that is of critical public health...

## Key facts

- **NIH application ID:** 10690931
- **Project number:** 3P20GM125507-05S1
- **Recipient organization:** RHODE ISLAND HOSPITAL
- **Principal Investigator:** JOSIAH D RICH
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $134,624
- **Award type:** 3
- **Project period:** 2018-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10690931

## Citation

> US National Institutes of Health, RePORTER application 10690931, COBRE Center on Opioids and Overdose (3P20GM125507-05S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10690931. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*