# Investigating the Cell Division Machinery

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $247,447

## Abstract

SUMMARY
Cell division is a complex and specifically orchestrated set of events that culminates in the equal
segregation of sister chromatids into two cells. It relies on a multitude of protein complexes, protein-
protein interactions, and regulatory mechanisms driven by the activities of posttranslational
modification enzymes. The Torres lab investigates the enzymes and regulatory mechanisms that are
necessary to carry out human cell division with high fidelity, which are often dysregulated in diseases
like cancer. Our research requires a microscope capable of imaging fixed and living cells with high
spatial and temporal resolution. This supplement requests funds to purchase a Leica MICA Widefield
Live Cell microscope, manufactured by Leica Microsystems, to replace the current broken
microscope in the Torres lab that has been continually used for over 12 years. The requested
microscope is necessary to continue to successfully complete the aims of the parent R35GM139539
grant, which still has over three years of funding.

## Key facts

- **NIH application ID:** 10690951
- **Project number:** 3R35GM139539-02S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Jorge Torres
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $247,447
- **Award type:** 3
- **Project period:** 2021-03-01 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10690951

## Citation

> US National Institutes of Health, RePORTER application 10690951, Investigating the Cell Division Machinery (3R35GM139539-02S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10690951. Licensed CC0.

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