# CORE B - Functional Outcomes Core

> **NIH NIH P01** · AUGUSTA UNIVERSITY · 2023 · $314,567

## Abstract

The purpose of the Functional Outcomes Core (Core B) is to provide a standardized set of musculoskeletal
assay services that will facilitate completion of the broader goals and objections of the Program Project goals
and specific aims. The objective of this Program Project application is to understand how AhR activation by Kyn
and its metabolites with aging induces muscle and bone loss. Each of the four projects investigates different
aspects of these signaling pathways, yet all will employ similar techniques and animal models. The Functional
Outcomes Core will provide each investigator with standard assay services in the areas of bone and muscle
histology and histomorphometry, imaging, densitometry, biomechanics, and serum biochemistry. Dr. Meghan
McGee-Lawrence will be the core director. She is a bone biologist with experience and expertise in the areas of
bone histomorphometry, densitometry, and biomechanics with particular emphasis on the use of animal models
in musculoskeletal research. She will be responsible for overseeing all administrative issues related to the Core
B facilities, as well as supervising the collection, preparation, and distribution of bone specimens. The Core will
serve as the major center for data collection related to bone and muscle metabolism, and as such represents a
key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support
of future research activities related to the objectives of the Program Project grant.

## Key facts

- **NIH application ID:** 10691490
- **Project number:** 5P01AG036675-12
- **Recipient organization:** AUGUSTA UNIVERSITY
- **Principal Investigator:** Meghan E. McGee-Lawrence
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $314,567
- **Award type:** 5
- **Project period:** 2011-05-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10691490

## Citation

> US National Institutes of Health, RePORTER application 10691490, CORE B - Functional Outcomes Core (5P01AG036675-12). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10691490. Licensed CC0.

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