# CORE C - Cellular Aging Core

> **NIH NIH P01** · AUGUSTA UNIVERSITY · 2023 · $314,181

## Abstract

Project Summary/Abstract
The Cellular Aging Core (Core C) will isolate and distribute bone marrow-derived mesenchymal stem/progenitor
cells (MSCs) from C57BL/6 mice, a common aging model for the Program Project, to the investigators of the
individual projects. Core C will also isolate and provide MSCs and myoblasts from project-specific genetically
altered (transgenic or knockout) mouse models. Furthermore, Core C will provide services for hypoxic cell
culture, multiplex cytokine assay and Seahorse mitochondrial function assays, as well as Cre-expressing
adenovirus production and infection. A key component essential to the success of the proposed Program Project
is the availability of MSCs because all projects require these cells. Thus, a centralized Core facility for the
production of quality cells, as well as providing standardized assays, are essential to the success of each
individual project, and the Program as a whole. This Core will benefit the research efforts of individual investigator
by reducing costs, providing quality control for study procedures, and enhancing collaborations among multiple
disciplines to achieve greater scientific gain through an integrated approach. In addition, production and
distribution of cells and service from a centralized facility will ensure that all studies start with cells of the same
lineages and background. By serving as a centralized resource for musculoskeletal progenitor cells and various
cellular assays, Core C will facilitate the collection of reproducible, accurate data concerning the role of
tryptophan (Trp) and kynurenine (Kyn) and their metabolites on bone and muscle in health and disease.

## Key facts

- **NIH application ID:** 10691493
- **Project number:** 5P01AG036675-12
- **Recipient organization:** AUGUSTA UNIVERSITY
- **Principal Investigator:** XINGMING SHI
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $314,181
- **Award type:** 5
- **Project period:** 2011-05-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10691493

## Citation

> US National Institutes of Health, RePORTER application 10691493, CORE C - Cellular Aging Core (5P01AG036675-12). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10691493. Licensed CC0.

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