# Increasing Availability of Emulsion Adjuvants via Synthetic Biology

> **NIH NIH N44** · ENEPRET, INC. · 2022 · $2,996,311

## Abstract

Squalene-based oil-in-water emulsions, such as MF59, have been shown to demonstrate adjuvant activity in a variety of vaccine settings, including seasonal influenza vaccine. The awardee seeks to develop a mimic of MF59 using squalene that has been sustainably synthesized by yeast cultures. This adjuvant will be tested in preclinical studies and advanced toward large production capacity.

## Key facts

- **NIH application ID:** 10691630
- **Project number:** 75N93022C00038-0-9999-1
- **Recipient organization:** ENEPRET, INC.
- **Principal Investigator:** CHASE KEMPINSKI
- **Activity code:** N44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $2,996,311
- **Award type:** —
- **Project period:** 2022-08-30 → 2025-08-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10691630

## Citation

> US National Institutes of Health, RePORTER application 10691630, Increasing Availability of Emulsion Adjuvants via Synthetic Biology (75N93022C00038-0-9999-1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10691630. Licensed CC0.

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