# Population-Scale Clinical Genomics

> **NIH NIH OT2** · HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY · 2022 · $2,607,081

## Abstract

The production of genomic data for the All of Us Research Program (AoU) is an unprecedented
opportunity to support a comprehensive precision medicine effort that benefits the entire U.S. population. With
the participation from patients, family members, researchers and clinicians, this opportunity will impact clinical
management by directing patient care, enabling pre-symptomatic genetic testing of relatives, guiding familyplanning
measures, and triggering healthcare interventions.
We propose to create the HudsonAlpha Consortium for Population Genomics (HACPG) for AoU as
a platform for high quality microarray, sequence, and clinical interpretation of high-value variants. The HACPG
will leverage the experience and breadth of our clinical team and consortium members to allow accurate and
cost-effective production of annotated variant data from the largest number of cases and samples possible.
The data we generate will be formatted and transferred to the program Data Resource Center (DRC) to
facilitate return of clinical results to the Genetic Counseling Resource as directed by the program. Our overarching
strategy in developing this proposal is to combine best-in-field teams to form a consortium dedicated to
enabling scalable genomics in an evolvable platform. This platform will easily support advancements in the
genomics field, efficiently combining existing technical and analytic resources. Our efforts will facilitate a path
to move unbiased genetic testing such as whole-genome sequencing to routine use in healthcare and lifestyle
management.
The roles and relationships of HACPG consortium members are summarized below (Fig 1.1). HACPG
is a collaboration between HudsonAlpha Institute for Biotechnology (lead institution, sequencing, and
clinical validation laboratory), Rutgers University (sample intake, quality control and genotyping), University
of Utah (data analysis), Fabric Genomics (clinical reporting) and Helix (return of results and value add). With
the significant expansion of sequencing volume in years 2-5 of AoU, the HACPG will expand to include Baylor
College of Medicine Human Genome Sequencing Center Clinical Lab (HGSC-CL) to provide a known and
trusted partner to expand the capacity of the consortium to support the requested volumes (see Letters of
Support 7.4 to 7.6 in Section 7).
As lead institution, HudsonAlpha Institute for Biotechnology benefits from a unique background.
HudsonAlpha was founded ten years ago with a mission to improve genomic literacy and support the
application of genomic technologies in education, research, healthcare and economic development. Since its
founding, HudsonAlpha has grown significantly in each of its mission areas and has made significant
contributions to the genomics field. Some key highlights and unique accomplishments with references to the
relevant sections of our proposal are:
• HudsonAlpha established the first CAP-accredited, CLIA licensed lab offering whole-genome
sequencing (WGS) and currentl...

## Key facts

- **NIH application ID:** 10692351
- **Project number:** 3OT2OD027070-01S1
- **Recipient organization:** HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY
- **Principal Investigator:** Jane Grimwood
- **Activity code:** OT2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $2,607,081
- **Award type:** 3
- **Project period:** 2019-09-21 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10692351

## Citation

> US National Institutes of Health, RePORTER application 10692351, Population-Scale Clinical Genomics (3OT2OD027070-01S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10692351. Licensed CC0.

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