# Remote STATE training for Insomnia in Older Adults

> **NIH NIH R44** · POSIT SCIENCE CORPORATION · 2023 · $467,378

## Abstract

PROJECT SUMMARY
The goal of the current Phase II project is definitively evaluate the efficacy of a computerized cognitive training
program (rSTATE) designed to improve sleep regulation and brain health and extend functional independence
in older adults with insomnia.
Nearly half of all adults over age sixty suffer disruptions in sleep that increase as a function of age. Nearly one
third meet criteria for chronic insomnia, resulting in poor quality of life and increased risk of depression.
Notably, cognitive decline in older adults with insomnia exceeds that observed in normal healthy aging. In
addition to the obvious health and quality-of-life ramifications of late life insomnia, there are high economic
costs. Thus, implementing scalable interventions to prevent functional dependence and cognitive impairment is
of critical importance to overall public health.
Here, we propose to evaluate a novel intervention that improve sleep, cognitive deficits and bolster functional
abilities in patients with insomnia. Our preliminary data is among the first evidence to demonstrate that a
neuroplasticity-based intervention has ‘real-world’ benefits and the potential to be a highly-scalable form of
computerized cognitive training for providing protection against insomnia.
At the completion of this project we will have outcomes data sufficient to support a compelling submission to
the FDA for clearance as a medical device indicated for the treatment of insomnia.

## Key facts

- **NIH application ID:** 10693814
- **Project number:** 5R44AG076304-02
- **Recipient organization:** POSIT SCIENCE CORPORATION
- **Principal Investigator:** Thomas VanVleet
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $467,378
- **Award type:** 5
- **Project period:** 2022-09-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10693814

## Citation

> US National Institutes of Health, RePORTER application 10693814, Remote STATE training for Insomnia in Older Adults (5R44AG076304-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10693814. Licensed CC0.

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