# Fibrinolysis Dysfunction Impact on Graft Function in Liver Transplantation

> **NIH NIH R00** · UNIVERSITY OF COLORADO DENVER · 2023 · $174,368

## Abstract

PROJECT SUMMARY/ABSTRACT
This is an application for a K99 award for Dr. Hunter Moore, a transplant surgery fellow at the University of
Colorado School of Medicine. Dr. Moore is establishing himself as a young investigator in patient-oriented
research with a translational focus on fibrinolysis and organ failure. This K99 award will provide him with the
mentored support necessary to accomplish the following goals; 1) Establishing a prospective outcome registry
to identify variables associated with graft dysfunction, 2) Training in advanced basic science methodologies of
quantifying fibrinolysis, 3) Integration of clinical and translation data to form a mechanistic hypothesis for
factors driving low fibrinolysis 4) Concurrent success in clinical training with maturation as a physician scientist.
Dr. Moore is supported by an expert multidisciplinary mentor team. Dr. Mitch Cohen will be his primary mentor;
he is a former K-08 recipient, and currently mentors three additional K award recipients. Dr. Cohen has been
researching coagulopathy for decades and currently runs a large NIH and DoD funded lab while serving as the
Chair of Surgery at an academic medical center. He will provide mentoring on establishing a successful
translational coagulation-based laboratory in addition to balancing clinical and research endeavors. Dr. Moore
has two basic science mentors: (1) Dr. Kirk Hansen, a recognized expert on mass spectrometry; he has
developed methods for defining tissue-specific proteomics, which will provide novel research approaches to
understand fibrinolysis at a local level, (2) Dr. Keith Neeves, an expert on flow-based coagulation; his
bioengineering expertise provides the mentorship for building models that simulate the microvasculature. Dr.
Angela Sauaia is a Professor in the School of Public Health, with extensive experience in translational
coagulation research; she will act as a mentor in building an outcomes database focused on graft function. Her
expertise in analyzing longitudinal data and variable reduction techniques will be critical for training Dr. Moore
in examining the temporal changes in fibrinolysis over time in the recipient, as well as the complex interactions
between the donor and recipient. The final core mentor is Dr. Trevor Nydam, who completed his transplant
fellowship at the University of Colorado and is the current fellowship program director. His insight in clinical
responsibilities and research are critical for success. Drs. Nydam and Moore will meet monthly and adjust
protected research and clinical training as needed to reach milestones in the parent application. Dr. Moore will
investigate the association of low fibrinolysis and microvascular clots in the organs of donors for Aim 1,
followed by Aim 2, defining the association between low fibrinolysis and impaired early graft function in liver
transplant recipients. Aim 3 will assess the donor organ local proteomes effect on forming fibrinolysis resistant
clots. These aims ...

## Key facts

- **NIH application ID:** 10693828
- **Project number:** 5R00HL151887-05
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Hunter B Moore
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $174,368
- **Award type:** 5
- **Project period:** 2021-09-01 → 2023-11-26

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10693828

## Citation

> US National Institutes of Health, RePORTER application 10693828, Fibrinolysis Dysfunction Impact on Graft Function in Liver Transplantation (5R00HL151887-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10693828. Licensed CC0.

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