# Regulation of gene transcription and alternative splicing by a long non-coding RNA

> **NIH NIH R01** · UNIVERSITY OF COLORADO DENVER · 2023 · $546,379

## Abstract

Project Summary/Abstract
Research over the past decade has revealed the importance of long non-coding RNAs (lncRNAs) in the control
of cardiac remodeling and heart failure. We have characterized a cardiac specific lncRNA in the control of
calcium handling in human and mouse cardiomyocytes. Knockout of this lncRNA causes dysregulation of
calcium handling in cardiomyocytes and impairs cardiac function. Knockout mice are susceptible to cardiac
arrhythmias caused by catecholaminergic challenging and premature death. In this project, we propose to (1)
determine mechanisms by which lncRNA regulates gene expression at the transcription level, (2) determine
how lncRNA regulates gene expression at the alternative splicing level, and (3) determine cardiac protection
conferred by lncRNA in response to pathological stresses. The results from this project have the potential to
facilitate the development of novel therapeutics for heart disease.

## Key facts

- **NIH application ID:** 10693874
- **Project number:** 5R01HL159086-02
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Kunhua Song
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $546,379
- **Award type:** 5
- **Project period:** 2022-09-01 → 2023-09-02

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10693874

## Citation

> US National Institutes of Health, RePORTER application 10693874, Regulation of gene transcription and alternative splicing by a long non-coding RNA (5R01HL159086-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10693874. Licensed CC0.

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