# U.S. Deprescribing Research Network

> **NIH NIH R24** · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · 2023 · $1,507,522

## Abstract

PROJECT SUMMARY / ABSTRACT
Deprescribing - the structured process of stopping unnecessary, potentially harmful, or goal-discordant
medications in a safe, effective, and patient-centered manner – holds great promise for improving the health
and well-being of older adults. Yet, research on deprescribing is fairly new, and much important work remains
to be done. To address this gap, we propose to establish a deprescribing research network that will catalyze
impactful research on deprescribing and build an interdisciplinary community of investigators working in this
field. We will achieve this using 2 complementary approaches. First, we will establish a series of cores focused
on Investigator Development, Stakeholder Engagement, Data and Resources, and Pilot and Exploratory
Studies, and a Leadership and Administration Core that will oversee the full range of network activities. These
cores will provide services and supports around learning, collaboration, investigator development, and pilot
funding. These activities will enhance investigators' abilities to conduct high-quality, interdisciplinary, and
stakeholder-informed research in deprescribing, and to compete successfully for future funding. Second, we
will convene a series of special projects, organized into 4 Working Groups. These projects will use a
combination of original research and consensus processes to develop new science and infrastructure in areas
that are critical for advancing deprescribing research for older adults. Each of these activities will focus on
older adults, particularly those with multiple chronic conditions and other sources of vulnerability, and the
network will be firmly rooted in the principles of aging research and geriatrics.
Consistent with the above goals, we have 6 specific aims. They are: (1) To develop a national community of
investigators interested in deprescribing and to support mutual learning and opportunities for collaboration that
will expand the quality, quantity, and translational impact of deprescribing research; (2) To create a
coordinated network of research sites that will generate science, address logistical and safety challenges, and
develop infrastructure to conduct clinical studies on deprescribing; (3) To develop and disseminate resources
to help investigators overcome common challenges in deprescribing research and maximize the scientific
validity and impact of scholarship in this area; (4) To support innovative pilot studies that address high-priority
topics in deprescribing and will catalyze future investigator development and larger-scale projects; (5) To
engage a broad range of stakeholders to maximize the relevance, sustainability, and dissemination potential of
research on deprescribing; and (6) To disseminate the work and findings of the network to a broad range of
external stakeholders and coordinate our efforts with other organizations and research networks.

## Key facts

- **NIH application ID:** 10693899
- **Project number:** 5R24AG064025-05
- **Recipient organization:** NORTHERN CALIFORNIA INSTITUTE/RES/EDU
- **Principal Investigator:** CYNTHIA Melinda BOYD
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,507,522
- **Award type:** 5
- **Project period:** 2019-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10693899

## Citation

> US National Institutes of Health, RePORTER application 10693899, U.S. Deprescribing Research Network (5R24AG064025-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10693899. Licensed CC0.

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