# Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center

> **NIH NIH U24** · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2022 · $89,267

## Abstract

PROJECT SUMMARY/ ABSTRACT
The overall objective of the Intestinal Stem Cell Consortium Coordinating Center (ISCC CC) is to maximize
scientific exchange and accelerate research, information, data, biomaterials, models, reagents, resources
and methods shared within the ISCC and with the research community. The goal of this grant proposal is to
continue to maintain and enhance the ISCC CC at City of Hope for another 5 years, working with
investigators from 9 Research Centers across the nation chosen by NIH to pursue the vision of developing novel
therapies targeting intestinal stem cells and their supportive niche to regenerate and rebuild the human intestine.
To achieve its mission of characterizing the minimal, required niche factors that support intestinal stem cells in
health and disease, the ISCC utilizes an integrated, multidisciplinary team science approach, which is a
network of synergistic projects focused on the following 3 Goals: Goal 1: To define essential niche components
that contribute to intestinal epithelial homeostasis, Goal 2: To determine niche components that are altered
following injury (infection, chemotherapy, radiation) and evaluate whether they play a role in epithelial
regeneration, and Goal 3: To develop a therapeutic approach for epithelial injury, using transplant, drugs, growth
and/or differentiating factors. The ISCC CC at COH is fully poised to continue to provide optimal research
infrastructure and support to the ISCC through the following specific aims: 1) To facilitate the necessary team
science administration of the ISCC; 2) To advance the collaborative science of the ISCC by providing study
development and analysis; 3) To coordinate standardized resources across the Consortium; and 4) To provide
data and information sharing within the ISCC and across the research community.

## Key facts

- **NIH application ID:** 10694316
- **Project number:** 3U24DK085532-14S1
- **Recipient organization:** BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- **Principal Investigator:** Joyce Carol Niland
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $89,267
- **Award type:** 3
- **Project period:** 2009-09-30 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10694316

## Citation

> US National Institutes of Health, RePORTER application 10694316, Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center (3U24DK085532-14S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10694316. Licensed CC0.

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