# Temperature-Controlled Recording System for Wireless Data Acquisition from Immature Rodents

> **NIH NIH R44** · BIOPAC SYSTEMS, INC. · 2023 · $709,817

## Abstract

Summary:
Biomedical research on rodent models of disease depends on research tools that not only facilitate the actual
experiments, but also improve reproducibility while enhancing animal care and welfare. In this SBIR
application, we propose to develop a complete “turn-key” system for studying physiological biopotentials
obtained from immature rodents (i.e., rat and mouse pups). Specifically, we intend to provide tools and devices
that will facilitate physiological experiments on immature rodents by designing, building, testing, and then
commercializing a wireless recording system with a focus on the electroencephalogram (EEG), a common
clinical tool. We will build and test a new temperature-controlled recording chamber, which is specifically
necessary for immature rodents because they cannot control their body temperature when separated from the
dam. This novel system will also allow investigators to simulate clinical hypothermia for rodent studies of the
EEG while modelling neonatal stroke and during the subsequent phases of brain injury. BIOPAC Systems, Inc.
will continue to collaborate with researchers at the University of Utah, and have already developed and tested
a proof of concept device. This collaboration will engage the engineering expertise of BIOPAC and
collaboratively build on the experience of the academic lab at the University of Utah to generate an optimized
system for recording and analysis of seizures and other EEG abnormalities similar to those used clinically. This
novel system will be a major extension of one of BIOPAC’s current products, the EPOCHTM miniature wireless
recording system, which was invented and patented at the University of Utah and is already commercially
available from BIOPAC. Upon completion, the novel EPOCHTM miniature wireless system will greatly facilitate
research on immature rodents as animal models of neurological disease and injury, while improving the
reproducibility and animal care for this type of research.

## Key facts

- **NIH application ID:** 10694512
- **Project number:** 1R44MH135715-01
- **Recipient organization:** BIOPAC SYSTEMS, INC.
- **Principal Investigator:** MANOEL ROWE
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $709,817
- **Award type:** 1
- **Project period:** 2023-09-14 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10694512

## Citation

> US National Institutes of Health, RePORTER application 10694512, Temperature-Controlled Recording System for Wireless Data Acquisition from Immature Rodents (1R44MH135715-01). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10694512. Licensed CC0.

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