# The genetic basis for age-related hearing loss in outbred mice

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 · $462,081

## Abstract

Summary
Age-related hearing loss (ARHL) has been linked to age-related cognitive decline. To date, no studies have
looked in detail at these two processes in a preclinical animal model. In this proposal we will, for the first time,
characterize the age-related changes in neural connectivity within the inner ear and brain in a premature aging
mouse model and explore the potential for two small molecules to prevent/regenerate these lost synapses.

## Key facts

- **NIH application ID:** 10694597
- **Project number:** 3R01DC018566-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Rick A Friedman
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $462,081
- **Award type:** 3
- **Project period:** 2020-09-18 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10694597

## Citation

> US National Institutes of Health, RePORTER application 10694597, The genetic basis for age-related hearing loss in outbred mice (3R01DC018566-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10694597. Licensed CC0.

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