# Research Services Core

> **NIH NIH P50** · EMORY UNIVERSITY · 2023 · $291,200

## Abstract

Project Summary – Research Services Core (Core B)
The Research Services Core (Core B) will be an essential part of the Emory Udall Center. The Core will have
three functions: (1) to prepare and process the brain tissue from experimental animals generated by the Center’s
projects, (2) to treat Rhesus monkeys systemically with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
and evaluate the resulting parkinsonism in a standardized manner, and (3) to provide biostatistical services and
consultation for all projects in the Center. The Core will provide standardized histology services to researchers
using animal models of parkinsonism (projects 1-3). These services will include the use of immunohistochemical
and microscopy approaches to evaluate the degree of dopamine depletion in 6-hydroxydopamine (6-OHDA) or
MPTP-treated animals (projects 1-3); histological reconstructions of recording electrode trajectories (projects 1
and 2); analysis of the degree and pattern of expression of transgenes (opsins, fluorescent proteins or voltage
sensors) after virus injections (projects 1-3). These services will be indispensable to interpret the functional
experiments and will help to compare and share the results among the projects. Similarly, all MPTP-treated
parkinsonian monkeys that will be used in projects 2 and 3 will be treated and evaluated using standardized
procedures by Core B personnel. This will help to integrate and compare data generated from these projects.
Finally, the Core will provide the services of a biostatistician that will advise and provide feedback on statistical
aspects of the projects. All four projects in the Udall Center will have access to these services, from the
conception and design of the experiments to the statistical analysis of experimental data. By providing these
services, the Core will help to free up time and resources from the research projects. In addition, center research
will benefit from the use of standardized, well-establish anatomical and behavioral assessment techniques, and
the biostatistical support will promote rigor and reproducibility in all projects.

## Key facts

- **NIH application ID:** 10695037
- **Project number:** 5P50NS123103-03
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Adriana Galvan
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $291,200
- **Award type:** 5
- **Project period:** 2021-09-29 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10695037

## Citation

> US National Institutes of Health, RePORTER application 10695037, Research Services Core (5P50NS123103-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10695037. Licensed CC0.

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