# Single Cell Transciptomics of the Opioid Use Disorder and HIV Syndemic in the Human Brain

> **NIH NIH UM1** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $394,997

## Abstract

Blood vessels that vascularize the central nervous system possess unique properties, termed
the blood-brain barrier (BBB), which imposes a tight regulation of molecules and cells
(particularly immune cells) that move between the blood and the brain. Disrupted BBB may
increase immune cell infiltrating into the brain parenchyma and promote glial activation,
increased inflammation and neurotoxicity. Interestingly, increased permeability of BBB has been
implicated in the progression of Alzheimer's disease. Differential gene expression among cell
types, and among individuals likely contributes to selective vulnerability or resilience. This
proposal will use single nucleus RNA sequencing to elucidate cell type selective transcriptomes
in leptomeninges and associate immune cells from AD and control cases. This work will lead to
fundamental advances in our knowledge of cell type specific genes regulating the
pathophysiology of neurovasculature and associate immune cell types in AD.

## Key facts

- **NIH application ID:** 10699022
- **Project number:** 3UM1DA051411-04S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Christine Cheng
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $394,997
- **Award type:** 3
- **Project period:** 2022-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10699022

## Citation

> US National Institutes of Health, RePORTER application 10699022, Single Cell Transciptomics of the Opioid Use Disorder and HIV Syndemic in the Human Brain (3UM1DA051411-04S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10699022. Licensed CC0.

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