# Tandem Multi-modal Plate Readers for a High Throughput Screening platform

> **NIH NIH S10** · UNIVERSITY OF FLORIDA · 2021 · $83,607

## Abstract

PROJECT SUMMARY:
The Scripps Research Molecular Screening Center (SRMSC) is requesting funds for the purchase of
two microplate readers as a replacement for its current uHTS Perkin Elmer Viewlux which has reached
end of life. The ViewLux has been the gold standard for high-speed microplate imaging; ideally suited
for simultaneous plate-well imaging analysis where speed, reliability and high quality data is required.
The integrated Viewlux reader on our HTS screening platform has served our needs admirably since
its initial installment in 2005. However, after ~15-years of service, reliability has become a critical issue
compounded by Perkin Elmer’s end of production (2017) and service support exacerbated by the
discontinued manufacture of all parts/components. As of date, there is not a current reader on the
market that equals the speed of the Viewlux, which is especially problematic with respect to ever
increasing need to perform low light luminescence and BRET readouts. Not surprisingly, many
comprehensive HTS screening centers (both Pharma & academic) must now rely on multiple readers
to meet HTS automation throughput needs while maintaining high quality and reliable data. High
Throughput Screening (HTS) has become an indispensable tool for probe development and drug
discovery and the Scripps Research Molecular Screening Center (SRMSC) has been in the forefront
in serving NIH investigators at Scripps and other academic institutes. Since establishing operations in
2005, we have screened over 300 targets to generate more than 100 million data points for our
collaborators at Scripps and at other institutions. Over 122 scientific papers and numerous
presentations demonstrate our ability to produce excellent research-driven data. Our screening results
have led to the development of over 77 bioactive molecular probes as novel drug targets for
biomedical studies that have successfully advanced as INDs for clinical trial testing and eventually
NDA/FDA drugs. The tandem multi-modal plate readers will replace the aged ViewLux; allowing
SRMSC to fulfill its current HTS screening obligations and continue to serve the NIH community at
large with its comprehensive HTS drug discovery capabilities.

## Key facts

- **NIH application ID:** 10702003
- **Project number:** 6S10OD030330-02
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Louis Daniel Scampavia
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $83,607
- **Award type:** 6
- **Project period:** 2021-04-01 → 2022-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10702003

## Citation

> US National Institutes of Health, RePORTER application 10702003, Tandem Multi-modal Plate Readers for a High Throughput Screening platform (6S10OD030330-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10702003. Licensed CC0.

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